RISK OF PROGRESSION

"Why is kidney size important for predicting the rate of disease progression?"

Kidney

"Why is kidney size important for predicting the rate of disease progression?"

Kidney size is a predictor for faster disease progression for ADPKD

A normal kidney weighs about a third of a pound. In ADPKD, because of the cysts, affected kidneys can grow to weigh many pounds. This increase in total kidney volume, or TKV, can be up to 4 times that of normal kidneys. As cysts grow, the kidneys continue to get bigger, and the damage continues to get worse. People with bigger kidneys are more likely to experience more rapid loss of kidney function than people with smaller kidneys.

Your eGFR may remain stable while your kidneys are growing

Kidney 1
Kidney 2
Kidney 3

Kidney function (eGFR)

Kidney size
(total kidney
volume)

Time

Slide the green dot above to see the growth of kidney size over time.

"How do I know if I’m at high risk of
faster disease progression?"

You may be at higher risk for faster disease progression if you:

Experience disease progression through the eyes of real people with ADPKD

ADPKD=autosomal dominant polycystic kidney disease; BMI=body mass index.

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